Needle-free expression line serum
Ditch the lines. Keep the expression.
Built on 4% SYN-AKE®, the maximum recommended concentration, for forehead lines, the 11s and crow's feet.
90 days to decide
If you don't see a difference, email us and we'll refund every dollar. Keep the bottle either way.
What's inside?
One 15 mL / 0.5 fl oz bottle. One bottle is one month.
Water, Glycerin, Niacinamide, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Zinc Oxide, Tocopheryl Acetate, Phenoxyethanol, Ethylhexylglycerin, Sodium Hyaluronate, Cyamopsis Tetragonoloba (Guar) Gum.
How to use it
Clean, dry skin. Morning and night.
Apply to your expression zones. Forehead, between the brows, outer eye area, smile lines.
Follow with moisturizer. Sunscreen in the morning, every morning.
- Fragrance free
- Non-comedogenic
- Vegan
- Cruelty free
- Made in USA
The problem
Expression lines don’t appear by accident.
- Smile.
- Squint at a screen.
- Raise your eyebrows.
- Frown at something you didn’t like.
Your face makes these movements thousands of times a day, and every time it does, skin folds in the same four or five places.
Take a piece of paper and fold it once. Let go and it mostly springs back.
Fold it in the same place a thousand times and it stops springing back. Now there’s a crease, and the crease is there whether you’re folding it or not.
That’s a wrinkle. Your face has been folding in the same four places your whole life.
Standard skincare works on the paper. Softer, smoother, better condition.
Nothing works on the folds themselves.
- Forehead lines The horizontal ones. Every raised eyebrow.
- The 11s Between the brows. Concentration, squinting, sunlight.
- Crow’s feet Outer corners of the eyes. Every real smile you’ve ever had.
- Smile lines Around the mouth and outer cheek.
The REFINE consumer perception study
We asked real REFINE users what they saw.
28 days
Did they see a difference?
60 days
Did it keep improving?
90 days
Are they keeping it in their routine?
438 REFINE users completed the 28-day checkpoint
After 28 days
89%
Said their expression lines and wrinkles looked softer
390 of 438 respondents
86%
Saw a noticeable difference compared with when they started
377 of 438 respondents
84%
Said their crow’s feet looked less pronounced
268 of 319 respondents
88%
Said they would keep using REFINE
385 of 438 respondents
And they kept going.
What happened after the first 28 days? We kept asking.
Day 60
Did it keep improving?
84%
Said their expression lines and wrinkles had continued to improve since Day 28
303 of 361 respondents
86% were glad they continued past the first 28 days · 310 of 361
Day 90
Are they keeping it in their routine?
91%
Said REFINE had earned a permanent place in their skincare routine
268 of 294 respondents
81% saw further improvement between Day 60 and Day 90 · 238 of 294
*Ongoing consumer perception study. 512 participants enrolled. 438 completed Day 28, 361 completed Day 60, and 294 completed Day 90. Results are participants’ self-reported perceptions, not instrument-measured clinical outcomes.
The gap
The fold only ever had one answer. Now it has two.
Look at what’s already on your bathroom counter.
A moisturizer, working on surface hydration. A retinol, working on cell turnover and texture. A vitamin C, working on sun and pollution damage.
All three are real. All three do what they say.
And none of them is aimed at the muscle that’s causing the wrinkle.
Because underneath every expression line is a muscle that pulls, thousands of times a day, folding the same piece of skin in the same place. That’s the fold. That’s the fourth target.
Three of these are covered by products you probably already own. The fourth is the one that makes the fold.
Only one thing has ever been aimed at the muscle, and it isn’t a serum.
A clinic. An appointment. A needle in your forehead every few months.
It works. That’s why people do it. But for a lot of people it’s a trade they’ve decided they don’t want to make, and until recently there was nothing else pointed at the muscle at all.
Now there’s a second answer.
A serum you apply twice a day, at home, that works on the muscle side of the problem. No needles. No appointments. No waiting room.
And nothing gets frozen or plastic.
Nothing is paralyzed. Nothing about your face stops working the way it does now. You keep every expression you have. What changes, gradually, is how deep a crease each one leaves behind.
Where it came from
It started with a snake that stops muscles from moving.
In the forests of Southeast Asia there is a snake called the temple viper.
Its venom contains a peptide called Waglerin-1. Waglerin-1 works by binding to the receiver that tells a muscle to contract. When it binds, the muscle stops moving without causing any damage to any part of the body.
Researchers looked at that peptide and asked a narrow question. Not how to use the venom. How to isolate the one short sequence responsible for that activity, and leave everything else behind.
They found it. Then they built it in a lab.
The result is SYN-AKE®, developed by Pentapharm in Switzerland and now produced by DSM. A synthetic peptide, under 500 daltons, small enough to move through the outer layer of skin.
There is no snake venom in this bottle.
There never was. No venom, no toxin, no animal source. SYN-AKE® is a lab-synthesized peptide modeled on one sequence from it, at a cosmetic concentration, on the surface of your skin.
One sequence. One receiver. One very specific job.
The temple viper takes its name from the Snake Temple in Penang, Malaysia, where the species has been part of the site for generations.
The mechanism
It works on the signal. Not just the surface.
Your facial muscles contract on a signal.
A nerve sends the signal. It lands on a receiving site on the muscle. It tells the muscle to pull, and the skin above it folds.
Every muscle has a limited number of those receiving sites.
SYN-AKE® was designed to block them.
Fewer open sites, less signal getting through.
Without the peptide
Receiving sites on the muscle
Full pull. Deep fold.
With 4% SYN-AKE®
Receiving sites on the muscle
Less pull. Less fold.
The muscle still contracts. It just contracts with less force, so the same expression leaves a shallower crease behind.
Not all of them. That’s the part that matters. Some sites stay open, which is why your face keeps doing everything it does now.
You keep every expression you have. The line it leaves gets softer and less visible.
This is a cosmetic serum applied to the surface of your skin. It is not a medical procedure and it doesn’t work like one. Nothing is paralyzed, nothing is frozen, nothing is permanent. The effect builds while you use it and fades gradually when you stop.
The payoff
Soften the line. Help keep it from getting deeper.
Expression lines get deeper through repetition. The same muscle contracts. The same skin creases. The same line gets folded again and again.
By reducing the repeated pull behind that crease, SYN-AKE® helps reduce the repeated creasing that can make the line deeper over time.
So REFINE doesn’t only help soften the expression lines you already have. It also helps reduce the repeated creasing that keeps reinforcing those same lines.
Today
Improve the line you see today.
Tomorrow
Help keep it from becoming a deeper crease tomorrow.
How the receptor interaction actually works
Muscle contraction begins when a nerve releases acetylcholine into the gap between the nerve ending and the muscle. The acetylcholine binds to a nicotinic acetylcholine receptor on the muscle side, and the muscle responds.
SYN-AKE® acts on the muscle side of that gap. In model systems it competes with acetylcholine for that receptor site and occupies it reversibly, so a smaller proportion of the signal produces a full-strength response.
That is a different point of action from peptides such as acetyl hexapeptide-8, which work on the nerve side by interfering with the machinery that releases acetylcholine in the first place. Same outcome sought, opposite end of the junction.
Regenyx does not claim medical neuromuscular effects. This mechanism is the biologically plausible explanation for the smoothing measured in ingredient-level studies, which is exactly what it is.
Can a peptide even get through skin?
Fair question, and for a lot of peptide products the honest answer is no.
Think of the outer layer of your skin as a screen door. Small things pass through, bigger things stay outside. That’s the entire job of that layer and it is very good at it.
Most peptides are too big for the mesh. They sit on the surface, do nothing, and get washed off.
The working threshold is generally put around 500 daltons, which is a measure of molecular size. SYN-AKE® is roughly 495. It was deliberately engineered down to the shortest sequence that still does the job, which is the only reason it can be a topical ingredient instead of an injectable one.
It barely fits. That’s the point.
The dose
There’s a difference between “contains SYN-AKE®” and “contains 4% SYN-AKE®.”
An ingredient can appear on a label at any amount. With expensive specialty peptides, that amount is usually the minimum required to print the name.
You’ve almost certainly bought a peptide serum before. You probably have no idea how much peptide was in it, because the brand didn’t tell you, because telling you wouldn’t have helped them.
Here’s what a trace amount actually means.
Imagine a recipe that calls for a cup of something and you put in a quarter teaspoon.
The ingredient is in the dish. You can list it on the menu. Nobody at the table is going to taste it.
That’s most peptide skincare. It’s legal, and it’s why you’ve probably bought a peptide serum before and felt nothing.
It happens because peptides are expensive.
A trace amount buys the name on the label at almost no cost. A real amount is one of the most expensive line items in the formula.
So most brands add trace amounts of a dozen marketable ingredients instead of a meaningful amount of one that works. You get a long, impressive-looking label and a product that does nothing.
We went the other way.
DSM publishes formulation guidelines for SYN-AKE®. For skin care preparations, the recommended range is 1 to 4%.
We use 4%.
The top of the manufacturer’s recommended range. The same concentration used in the ingredient’s own clinical testing.
Not a sprinkle. Not enough to make the claim. The full recommended maximum.
Dose comparison
Concentration of SYN-AKE® supplied solution. The trace figure is illustrative of category practice, not a measurement of a named competitor.
Let’s be precise about what 4% means.
SYN-AKE® doesn’t arrive as a powder. It comes from the manufacturer as a glycerin-based solution, and 4% refers to that solution. Four percent of this bottle is not pure peptide. Nobody’s bottle is. It can’t be. That much peptide would melt your face.
Four percent of the supplied solution is the number that matters, because it’s the number the formulation guidelines use and the number the clinical work was run at. It’s the top of DSM’s recommended range.
We’re telling you this because we believe in transparency. We are using the absolute maximum amount of SYN-AKE® to achieve maximum results with no adverse effects. Most products containing this ingredient use a fraction of what we use.
Two peptides do this job. We picked the one with the head-to-head win.
There are two well-studied peptides for expression lines, and they work at opposite ends of the same junction.
Acetyl hexapeptide-8, sold as Argireline, works on the nerve side, interfering with the release of the signal before it crosses. It’s a legitimate ingredient with real published data behind it, and it’s in most of this category’s products for good reason.
SYN-AKE® works on the muscle side, at the receiving site itself.
Concentration isn’t the whole story. Where a peptide “acts” matters more than how much of it you use.
The cosmetic industry has tested that directly.
Forty-five people, twenty-eight days, twice daily, three groups. One group used 4% SYN-AKE®. One used 10% acetyl hexapeptide-8, the peptide in most wrinkle serums. One used a placebo.
The lower concentration won. Because it was the best peptide for the specific job of reducing wrinkles.
4% beat 10%. And not by a little.
Twenty-one percent smoother skin against four. Twenty percent less wrinkle depth against two.
Less than half the concentration, but roughly five times the result.
That’s why REFINE is the right choice for targeting expression lines.
Head to head
45 participants, 28 days, twice daily, double-blind, three arms including placebo. Both bars in each pair use the same navy at different values; neither ingredient is coded as bad. Measured by profilometry. Ingredient-level results, not clinical outcomes for this finished product.
The formula
Target the fold first. Then improve the skin around it.
SYN-AKE® is the engine.
REFINE starts with the target most wrinkle products miss: the repeated muscle movement that keeps folding the same skin into the same crease.
Then the rest of the formula works on the skin taking that fold: hydrating and plumping it now, helping it hold onto that moisture, and improving the appearance of fine lines, texture and elasticity over time.
01
Reduce the pull
02
Plump the skin
03
Strengthen the barrier
Ten ingredients. Three jobs. One objective.
Make expression lines look softer, smoother, and less visible.
01
Interrupt · 4% SYN-AKE®
Reduce the pull behind the crease.
Repeated contraction keeps folding the same skin in the same place. 4% SYN-AKE® targets the signal involved in that repeated movement, helping reduce the repeated creasing behind the line.
02
Plump · HA + Glycerin
Hydrate and plump the skin around the line.
Dry, depleted skin makes a crease look sharper. Glycerin and sodium hyaluronate draw and hold water in the upper layers of the skin, helping the skin around the line look fuller, smoother and better hydrated.
03
Strengthen · Niacinamide
Strengthen the barrier and improve the skin over time.
Niacinamide helps strengthen the skin’s moisture barrier so it can hold onto hydration better. With continued use, it also helps improve the appearance of fine lines and wrinkles, texture and elasticity.
So while SYN-AKE® targets the repeated movement behind the crease, the rest of the system helps improve the skin that crease is showing through.
Reduce the pull. Plump the skin. Strengthen the barrier.
Every ingredient. What it’s doing in there.
REFINE uses ten ingredients. The formula is deliberately focused: a three-part core system, supported by the ingredients needed to condition, preserve and give the serum its finished texture.
The core system
4
SYN-AKE® Interrupt
Dipeptide Diaminobutyroyl Benzylamide Diacetate
The engine. Used at 4%, the top of the manufacturer-recommended range.
Glycerin Plump
Draws and holds water in the upper layers of the skin.
Hyaluronic Acid Plump
Sodium Hyaluronate
Hydrates and visibly plumps the skin around the line.
Niacinamide Strengthen
Supports the moisture barrier and helps improve the appearance of fine lines, texture and elasticity over time.
Supporting formula
6
Vitamin E Condition
Tocopheryl Acetate
Conditions the skin and provides antioxidant support.
Zinc Oxide Formula
Helps soothe and protect the skin while supporting the finished formula.
Water Base
The purified base that carries the formula.
Phenoxyethanol + Ethylhexylglycerin Preserve
Keeps the formula fresh and protected from microbial contamination.
Guar Gum Texture
Cyamopsis Tetragonoloba Gum
Gives the serum its smooth texture and helps it spread evenly.
That’s the entire list. Ten.
No sprawling ingredient deck. No dozen trendy actives competing for space on the label. The formula stays focused on the job REFINE was built to do.
No Fluff. No Filler.
The data
What the research actually shows.
Three different jobs. Three different timelines. And published research behind each one.
01 · Interrupt · 4% SYN-AKE®
28 days · twice daily
In ingredient-level studies using 4% SYN-AKE®:
15–20%
shallower wrinkle-depth measurements
21%
smoother skin surface
Up to
52%
reduction in wrinkle depth among the best responders
~80%
of participants showed measurable smoothing
REFINE uses the same 4% SYN-AKE® concentration and twice-daily use model.
This is the engine: reduce the repeated pull behind the crease.
Ingredient-level SYN-AKE® research using formulations containing 4% SYN-AKE®. Individual results vary.
02 · Plump · Hyaluronic acid
Immediately → 6 weeks
In a published six-week facial hyaluronic-acid serum study:
134%
increase in hydration after the first application
55%
higher hydration at 6 weeks
31%
improvement in fine lines
14%
improvement in wrinkles
More hydrated skin looks fuller and smoother, helping fine lines and shallow wrinkles look softer and less sharply defined.
This is the fast surface effect: hydrate and plump the skin around the line.
Published 6-week facial hyaluronic-acid serum study, 40 subjects. Ingredient/formulation research.
03 · Strengthen · Niacinamide
12 weeks · twice daily
In randomized, double-blind facial research using 5% topical niacinamide:
~5%
reduction in total wrinkle line length vs. control
Elasticity
Significant improvement in skin elasticity
Texture
Significant improvement in skin texture
Tone
Significant improvement in uneven-looking tone
Niacinamide also supports the skin’s moisture barrier, helping skin retain hydration and become more resilient-looking over time.
This is the long game: improve fine lines while strengthening the skin around them over time.
Randomized, double-blind, split-face study in 50 women using 5% niacinamide twice daily for 12 weeks versus a control formulation. Ingredient-level research.
Different mechanisms. Different timelines. One reason they’re together: expression lines look better when you address both the repeated crease and the skin it’s showing through.
The timeline
The science matters. The mirror matters more.
28 days is the on-ramp, not the finish line.
REFINE starts working on different parts of the problem at different speeds. Hydration can show up quickly. Expression-line changes build over the first month. And the skin around those lines can keep improving well beyond Day 28.
Here’s what to look for, and roughly when.
Days 1–2
The first thing you notice
Hydration.
Glycerin and hyaluronic acid start pulling moisture into the upper layers of the skin from the first applications.
Skin can look fuller, smoother and less dry. Fine lines can look softer and less sharply defined.
This is the fast side of REFINE.
Days 7–14
The first expression-line change.
This is where the SYN-AKE® research begins showing early visible change.
Look at the lines that appear when your face moves: the forehead, the 11s and crow’s feet.
They won’t disappear overnight. What you’re looking for is the beginning of a softer, less pronounced crease.
This is why you took the Day 1 photo.
Day 28
The checkpoint.
By Day 28, the expression-line effect should be much easier to judge.
This is the primary checkpoint used in the 4% SYN-AKE® research, where researchers measured shallower wrinkle depth and smoother skin surface after twice-daily use.
Retake your Day 1 photos. Same light. Same angle. Face relaxed. Then fully expressive.
Don’t judge from memory. Compare the pictures.
Day 28 is the checkpoint. Not the finish line.
Weeks 6–12
The whole area keeps getting better.
Now the longer-term side of the formula has had more time to work.
Continued hydration helps keep the skin looking fuller and smoother. Niacinamide supports the moisture barrier while progressively improving the appearance of fine lines and wrinkles, texture and elasticity.
The result is bigger than what happens to one crease. That’s why Day 60 and Day 90 matter.
The whole area can look smoother, healthier and more refined.
Beyond
Maintenance with momentum.
Keep using REFINE and you’re doing two things at once.
You’re maintaining the expression-line effect you’ve built with SYN-AKE® while continuing to support the hydration, barrier and overall quality of the skin around those lines.
The expression-line effect is reversible by design, so consistency matters. At the same time, the rest of the formula keeps supporting the skin around the line.
It’s about maintaining the result while continuing to improve the skin around it.
28 days is the checkpoint. Give it 90 to see how far you can take it.
1 bottle · 30 days
Reach the first major SYN-AKE® expression-line checkpoint.
2 bottles · 60 days
Keep building momentum as hydration and the wrinkle reduction part of the formula continue to work.
3 bottles · 90 days
Give the complete REFINE system time to work together: softer-looking expression lines, smoother-looking skin, and continued improvement in the area around them.
Day 28 is your first real checkpoint. Day 90 shows you how far consistent use can take you.
That’s why the 90-day option is the one we recommend.
You’ve got 90 days to decide either way.
REFINE
SYN-AKE® works while you use it and fades gradually when you stop. This one is built for staying on it.
90-day guarantee · Ships from Texas
The routine
Twice a day. That’s the whole protocol.
01
Clean, dry skin. Morning and night.
02
Apply to your expression zones. Forehead, between the brows, outer eye area, smile lines.
03
Follow with moisturizer. Sunscreen in the morning, every morning.
Lightweight and water-based. Absorbs in under a minute, no film, no fragrance, nothing added for scent.
Zones, layering, and how to track results
It doesn’t have to stop at your face
The clinical data was measured on forehead, brow, and crow’s feet. Those are the zones to prioritize.
But the same three things are true of other skin that moves and gets sun. Neck lines and tech-neck rings come from constant flexion. The backs of your hands are thin, exposed, and show crepiness earlier than almost anywhere.
The mechanisms don’t change when you move down. The data just hasn’t been measured there.
If your neck or your hands are on your list, include them in your routine, you’ll be surprised by the results. Add a second pump, and expect a bottle to go faster than 30 days.
Where it goes in your routine
This is a lightweight water-based serum, so it goes on early. Clean skin, then this, then anything heavier.
It works alongside retinol, vitamin C, moisturizer, and sunscreen. Nothing in this formula conflicts with them.
Sits under makeup without pilling.
External use only. Avoid direct contact with the eye.
Take the before photo. Today.
Nobody remembers what their forehead looked like four weeks ago. Everybody thinks they will.
Before your first application:
- Good, even light. Same spot every time, ideally a window in daylight.
- Face relaxed and neutral.
- Then brows fully raised.
- Then a full squint and a real smile.
This is the only way to actually see a change that happens gradually. It’s also the difference between judging the product and guessing at it.
Day 28 · The checkpoint
Take the same photos again. Same light. Same angle. Same expressions.
This is the primary SYN-AKE® expression-line checkpoint. Put Day 1 and Day 28 side by side and look for the difference.
Don’t judge from memory. Compare the pictures.
Day 60 · Keep building
By now, you’ve had another full month beyond the primary expression-line checkpoint.
Compare Day 60 to Day 1. Look at the expression lines, but also look at the skin around them as hydration and the longer-term side of the formula continue to build.
Day 90 · See how far you’ve come
Put Day 1 and Day 90 side by side.
By now you’ve given the complete formula time to work across its different timelines: immediate hydration, the earlier SYN-AKE® expression-line effect, and the longer-term skin benefits of continued use.
You don’t wait 90 days for REFINE to start working. You give it 90 days to see how far you can take it.
The questions we get
Straight answers.
Is there snake venom in this?
No. No venom, no toxin, no animal-derived material. SYN-AKE® is a fully synthetic peptide modeled on one short sequence from a venom peptide. Nothing else from the venom was used or recreated.
Will my face look frozen?
No. This is a topical cosmetic serum applied to the surface of your skin, not a medical procedure.
Your expressions don’t change. Nothing is paralyzed. No plastic face. What changes, is how deep a crease your expressions leave behind.
Is it safe for sensitive skin?
Ten ingredients, no fragrance, no essential oils, no dye. That’s a short list of things to react to, which is one of the advantages of a minimal formula.
Occasional mild, transient tingling has been reported with SYN-AKE® formulas. If you’re reactive or allergy-prone, patch test on a small area first.
Can I use it around my eyes?
Apply to the outer eye area and crow’s feet. Avoid direct contact with the eye itself. If it gets in your eye, rinse thoroughly.
Can I use REFINE with retinol or vitamin C?
Yes. REFINE can be used alongside retinol, vitamin C, moisturizer and other common skincare products.
Apply REFINE to clean, dry skin, let it absorb, then continue with the rest of your routine.
Will REFINE help keep my expression lines from getting deeper?
Yes. Expression lines deepen through repeated creasing. SYN-AKE® helps reduce the repeated pull behind that crease, so consistent use can help soften the lines you have while reducing the repeated creasing that can make them deeper over time.
Improve the line you see today. Help keep it from becoming a deeper crease tomorrow.
How quickly should I see results?
You don’t have to wait 90 days to start seeing a difference.
The hydration side of REFINE begins working from the first applications, helping skin look fuller, smoother and less dry.
SYN-AKE® research begins showing early visible expression-line changes around Days 7–14, with Day 28 as the primary expression-line checkpoint.
From there, continued hydration and niacinamide give the skin around those lines more time to improve through Days 60 and 90.
Day 28 is the checkpoint. Give it 90 to see how far you can take it.
What happens if I stop using it?
Yes, continued use matters if you want to maintain the SYN-AKE® expression-line effect.
The effect is reversible, so consistent use matters. Continued use also gives the hydration and skin-support side of the formula more time to keep working.
Think maintenance with momentum.
Does this work for men?
Yes. The mechanism has nothing to do with gender. Men often have deeper forehead lines and stronger 11s, partly from thicker skin and partly from decades of less sun protection, and those are the two zones this was built for.
How long does a bottle last?
One bottle is 15 mL / 0.5 fl oz, approximately a 30-day supply when REFINE is used as directed, morning and night.
That’s why the 1-, 2- and 3-bottle options correspond to approximately 30, 60 and 90 days of use.
How should I store it, and how long is it good for?
Room temperature, out of direct sunlight. No refrigeration needed. Six months once opened, as indicated on the carton.
How long does shipping take?
2 to 3 business days within the US. Ships from Texas.
What exactly is SYN-AKE®?
A synthetic peptide developed by Pentapharm in Switzerland and now produced by DSM. It’s modeled on one sequence from Waglerin-1, a peptide found in temple viper venom. INCI name: Dipeptide Diaminobutyroyl Benzylamide Diacetate.
Where is it made, and do you test on animals?
Assembled in the USA. Cruelty free. No animal testing.
Is it vegan?
Yes. Regenyx Refine is a vegan formula.
How do I reach a human?
We work Monday through Friday, 9 to 5 Central Time, and you can reach us at support@regenyx.life.
Your lines look softer, or you don’t pay for it.
You have 90 days. The research ran 28, so use it twice a day for at least that long and take a photo before you start.
If you don’t see a difference, email us and we’ll refund every dollar. No restocking fee, no partial, nothing to send back and nothing to prove.
Keep the bottle either way.
Regenyx
REFINE
SYN-AKE® works while you use it and fades gradually when you stop. This one is built for staying on it.
90-day guarantee · Ships from Texas